Laser Speckle Imaging System
Ib qho kev cuam tshuam cov qauv / speckle qauv yog tsim ntawm lub ntes thaum lub teeb coherent siv los ua kom pom cov ntaub so ntswg lom. Laser speckle contrast imaging yog raws li qhov kev hloov pauv hauv lub teeb rov qab vim muaj kev cuam tshuam nrog cov qe ntshav liab (RBCs). Particle txav hauv cov ntaub so ntswg ua rau muaj kev hloov pauv hauv cov qauv speckle, ua rau qhov muag plooj ntawm cov duab speckle thaum cov duab no tau txais nrog lub sij hawm raug ntev dua los yog sib npaug ntawm speckle fluctuation time scale. Qhov no qhov muag plooj tuaj yeem raug ntaus nqi rau cov ntshav ntws yog tias qhov hloov pauv tau tshwm sim los ntawm RBC txav.
Hauj lwm lawm
Tuam txhab Profile
Guangzhou G-Cell Technology Co., Ltd. yog lub tuam txhab thev naus laus zis tshiab tsim los ntawm kev cia siab rau Tsinghua University Shenzhen Kawm Tiav Tsev Kawm Ntawv, Southern University of Science thiab Technology, thiab South China Normal University, thiab peb tsom mus rau daim ntawv thov ntawm optical imaging technology nyob rau hauv lub teb ntawm life sciences. Rau cov chav nyob hauv cov lus qhia txog kev thov, peb tuaj yeem muab koj cov khoom siv kho qhov muag pom kev thiab cov kev daws teeb meem. Peb muaj qhov ua tiav qhov kev sim kho qhov muag sim platform thiab ib pab pawg ntawm cov tub ntxhais hluas cov pob txha zoo. Raws li kev sib koom ua ke ntawm cov khoom siv hauv chav kuaj thiab kev lag luam hauv Is Taws Nem, lub tuam txhab tau cog lus los tsim lub cim tshiab ntawm cov khoom siv ntse ntse.
Vim Li Cas Xaiv Peb
Pab neeg ua haujlwm
Peb tshwj xeeb hauv kev siv thev naus laus zis kho qhov muag rau thaj tsam ntawm cell biology. Rau kev tshawb fawb ntawm tes, kev soj ntsuam thiab lwm daim ntawv thov teb.Peb muaj qhov ua tiav kev sim kho qhov muag sim platform thiab ib pawg ntawm cov tub ntxhais hluas cov pob txha zoo tshaj plaws.
Cov cuab yeej siv siab heev
Raws li kev sib koom ua ke ntawm cov khoom siv hauv chav kuaj thiab kev lag luam hauv Is Taws Nem, lub tuam txhab tau cog lus los tsim lub cim tshiab ntawm cov khoom siv ntse ntse.
Kev tshawb fawb ywj pheej thiab kev txhim kho
Raws li kev tsim kho tshiab ntawm pab pawg tshawb fawb thiab kev txhim kho muaj zog, GCell cov khoom lag luam tau txais kev ywj pheej tshawb fawb thiab kev tsim kho, kev tsim khoom ywj pheej, kev ywj pheej patents, thiab tau dhau ntau daim ntawv pov thawj xws li software monographs thiab cov qauv siv hluav taws xob patents.
Software zoo
Software tuning yog nqa tawm raws li kev siv tus cwj pwm ntawm cov neeg siv tshawb fawb tshawb fawb, thiab cov txiaj ntsig tau raug xa tawm raws li qhov xav tau ntawm cov ntawv tshawb fawb tshawb fawb thiab cov ntawv ceeb toom. Daim ntawv saib ua ntej cov ntaub ntawv tuaj yeem muab rov qab tau txhua lub sijhawm, thiab kev txhawb nqa kev hloov pauv ntawm cov txiaj ntsig panoramic, uas yooj yim rau kev tshawb fawb thoob ntiaj teb.
Yam khoom
Dab tsi yog Laser Speckle Imaging System
Ib qho kev cuam tshuam cov qauv / speckle qauv yog tsim ntawm lub ntes thaum lub teeb coherent siv los ua kom pom cov ntaub so ntswg lom. Laser speckle contrast imaging yog raws li qhov kev hloov pauv hauv lub teeb rov qab vim muaj kev cuam tshuam nrog cov qe ntshav liab (RBCs). Particle txav hauv cov ntaub so ntswg ua rau muaj kev hloov pauv hauv cov qauv speckle, ua rau qhov muag plooj ntawm cov duab speckle thaum cov duab no tau txais nrog lub sij hawm raug ntev dua los yog sib npaug ntawm speckle fluctuation time scale. Qhov no qhov muag plooj tuaj yeem raug ntaus nqi rau cov ntshav ntws yog tias qhov hloov pauv tau tshwm sim los ntawm RBC txav.
Qhov zoo ntawm Laser Speckle Imaging System
Kev saib xyuas lub sijhawm tiag tiag
Lub kaw lus muab kev saib xyuas cov ntshav hloov pauv hauv lub sijhawm, ua rau nws muaj txiaj ntsig zoo rau kev tshawb fawb dynamic thiab tawm tswv yim tam sim ntawd thaum sim lossis cov txheej txheem kho mob.
Kev daws teeb meem siab
Laser speckle imaging muab siab spatial daws teeb meem, ua kom cov ncauj lus kom ntxaws pom ntawm microvascular tes hauj lwm thiab perfusion qauv hauv cov ntaub so ntswg.
Ntau yam
Laser speckle imaging yuav siv tau nyob rau hauv ntau yam teb, xws li neuroscience, ophthalmology, dermatology, cardiovascular kev tshawb fawb, thiab preclinical kev tshawb fawb, qhia tau hais tias nws versatility.
Dynamic ntau yam
Laser speckle imaging systems muaj ntau yam dynamic ntau, tso cai rau kev tshawb pom ntawm ob qho tib si qeeb thiab ceev ntshav hloov pauv hauv cov ntaub so ntswg.
Keeb kwm thiab kev lag luam xav tau rau Laser Speckle Imaging System
Lub circulatory system yog ib tug tas mus li kaw system ntawm ducts faib thoob plaws hauv lub cev, nrog rau cov hlab plawv system thiab lymphatic system. Dab tsi circulates nyob rau hauv lub plawv system yog ntshav. Dab tsi ntws los ntawm lymphatic system yog lymph. Cov kab mob lymphatic kuj tseem tuaj yeem xav tias yog ib feem ntawm cov hlab ntsha ntawm cov hlab ntsha, vim cov lymphatic ntws hauv nruab nrab los ntawm cov kav dej lymphatic uas thaum kawg ntws mus rau hauv cov leeg.
Lub paj hlwb tsis muaj nws tus kheej lymphatic network, tab sis daim nyias nyias nyob ib ncig ntawm lub hlwb, hu ua meninges, muaj cov hlab ntsha lymphatic. Extravasated erythrocytes nyob rau hauv cerebrospinal kua (CSF) tseem ceeb heev pab rau lub pathogenesis ntawm subarachnoid hemorrhage (SAH). Ib tug subarachnoid hemorrhage txhais tau hais tias muaj los ntshav nyob rau hauv qhov chaw uas nyob ib ncig ntawm lub hlwb. Nws yog ib qho mob hnyav heev thiab tuaj yeem ua rau tuag taus.
Meningeal lymphatics tau tshaj tawm kom ntws macromolecules thiab lub cev tiv thaiv kab mob los ntawm CSF mus rau hauv lub ncauj tsev menyuam qog (CLNs). Txawm li cas los xij, seb meningeal lymphatics puas koom nrog kev tshem tawm cov erythrocytes extravasated hauv CSF tom qab SAH tseem tsis meej.
Kev kuaj pom, kev ua cov ntaub so ntswg yog ua tiav los txiav txim siab txog kev ua haujlwm ntawm meningeal lymphatics, tab sis cov kev hloov pauv hauv cerebral ntshav ntws tom qab lymphatic ablation yuav tsum tau soj ntsuam kom muaj nuj nqis los ua kom tag nrho cov kev tshawb fawb tiav, vim tias tsuas muaj peb lub hauv paus hauv lub hlwb, lymphatic network, vascular. system thiab cerebrospinal kua ncig.
Nws technology zoo yog nws tsis sib cuag, tsis muaj qhov sib txawv tus neeg sawv cev yuav tsum tau, siab ncej-tus nqi, siab spatial daws teeb meem. Lawv tuaj yeem siv los soj ntsuam thiab sau cov ntshav perfusion ntawm cov ntaub so ntswg los yog cov khoom nruab nrog cev rau kev kawm microcirculation lossis kev tshawb fawb ua ntej xws li ischemic stroke, qis qis, mesentery, thiab lwm yam. Cov zis ntau yam suav nrog cov ntshav perfusion thiab cov yeeb yaj kiab (500+ lab pixels), quantified cov ntaub ntawv rau perfusion unit thiab hlab ntsha txoj kab uas hla.
Lub koob yees duab kaw thoob ntiaj teb built-in tuaj yeem ua tiav cov ntaub ntawv tau txais sai dua thiab ua haujlwm nrawm. Qhov zoo tshaj plaws kho qhov muag daws teeb meem ntawm 3.9 μm / pixel, muab cov ntaub so ntswg ntxaws ntxiv. Max ncej tus nqi (tag nrho cov teb) mus txog 100 fps, tau txais kev hloov pauv ntawm lub sijhawm hauv thaj chaw loj. Motorized 10x optical zoom thiab nws pib ua kom pom tseeb. Duab loj li ntawm 0.57 × 0.75 mus rau 22.5 × 30 cm2 nyob rau hauv tag nrho-nyob rau hauv-ib imager, npog ntau yam kev tshawb fawb daim ntaub ntawv. Nws pib ceev ceev thiab ua kom pom tseeb ntawm phau ntawv qhia, txhim kho kev ua kom pom tseeb thiab raug ntawm ntau cov ntaub so ntswg. Optimal lens sib dhos, lim lub ambient thiab reflecting lub teeb. Chav Kawm 1 ntawm kev ntsuas thiab qhia cov lasers, muaj kev nyab xeeb siv yam tsis muaj qhov muag tiv thaiv. Laser stability hardware rau qhov kawg ntawm kev txhim khu kev qha thiab zoo ib yam ntsuas nyob rau hauv feeb, teev thiab hnub. Calibration nrog calibration box. Kev ntsuas tus kheej tuaj yeem ua tau txhua lub sijhawm kom cov cuab yeej ua haujlwm tau zoo. Ua rau hauv / tawm BNC kev sib txuas rau kev sib txuas lus nrog cov khoom siv sab nraud. Unlimited installation ntawm tsom xam software hauv PC.
Kev Txhim Kho Keeb Kwm ntawm Speckle Contrast Imaging ntawm Laser Speckle Imaging System
Laser speckle contrast imaging (LSCI), tseem hu ua laser speckle imaging (LSI), yog ib qho kev ntsuas kev ntsuas raws li kev txheeb xyuas ntawm qhov tsis pom kev ntawm cov qauv speckle. Kev ua haujlwm ntawm LSCI yog muaj qhov dav-teeb pom kev ntawm qhov chaw ntxhib los ntawm lub teeb ci sib txuas. Tom qab ntawd siv photodetectors xws li CCD lub koob yees duab los yog sensors imaging lub resulting laser speckle qauv tshwm sim los ntawm kev cuam tshuam ntawm coherent lub teeb. Hauv kev siv biomedical, lub teeb coherent feem ntau yog nyob rau thaj tsam liab lossis ze-infrared kom ntseeg tau tias muaj kev nkag siab ntau dua. Thaum tawg cov khoom txav mus rau lub sijhawm, qhov cuam tshuam los ntawm lub teeb sib xyaw ua ke yuav muaj qhov hloov pauv uas yuav ua rau muaj qhov sib txawv ntawm qhov ntsuas pom los ntawm photodetector, thiab qhov kev hloov ntawm qhov siv no muaj cov ntaub ntawv ntawm cov khoom tawg. Los ntawm cov duab cov qauv speckle nrog lub sijhawm raug txwv, thaj chaw uas muaj cov khoom tawg yuav tshwm plooj.
Cov thev naus laus zis no hu ua single-exposure speckle photography thaum ntawd. Vim tias tsis muaj cov txuj ci digital txaus, kev yees duab ib leeg raug pom muaj ob kauj ruam uas ua rau nws tsis yooj yim thiab muaj txiaj ntsig txaus rau kev tshawb fawb biomedical tshwj xeeb hauv kev siv tshuaj kho mob. Nws tsis tas yuav siv cov duab los ntes cov duab. Cov thev naus laus zis zoo dua yog hu ua laser speckle contrast imaging (LSCI) uas tuaj yeem ntsuas qhov sib piv ntawm speckle qauv ncaj qha. Ib qho kev ntsuas kev teeb tsa ntawm laser speckle contrast imaging tsuas muaj lub laser qhov chaw, lub koob yees duab, diffuser, lens, thiab computer. Vim yog cov qauv yooj yim ntawm kev teeb tsa, LSCI tuaj yeem ua ke rau hauv lwm lub tshuab tau yooj yim.
Tswv yim xav txog Laser Speckle Imaging System
Ntau qhov kev ntsuas yuav tsum tau coj mus rau hauv kev txiav txim siab rau qhov sib txawv siab tshaj plaws thiab teeb liab rau suab nrov piv (SNR) ntawm LSCI. Qhov loj ntawm tus kheej speckle yog qhov tseem ceeb thiab nws yuav txiav txim siab qhov yuav tsum tau muaj ntawm photodetector. Qhov loj ntawm txhua tus qauv speckle yuav tsum me dua li tus photodetector lub pixel loj kom tsis txhob muaj qhov sib piv. Qhov tsawg kawg nkaus speckle txoj kab uas hla rau LSCI system nyob ntawm lub wavelength ntawm lub teeb, imaging system magnification, thiab imaging system f-number.
Static scatters yog qhov tsim nyog, vim lawv tuaj yeem txiav txim siab qhov sib txawv siab tshaj plaws ntawm LSCI system tuaj yeem tau txais. Ob qho tib si luv luv lossis ntev dhau lawm (T) tuaj yeem txo qhov ua tau zoo ntawm LSCI system vim tias qhov raug luv luv tsis tuaj yeem ua kom cov photons txaus los khaws cia thaum lub sij hawm ntev dhau los tuaj yeem txo qhov sib piv. Tsim nyog T yuav tsum tau soj ntsuam ua ntej. Lub kaum sab xis illumination yuav tsum tau txiav txim siab kom ua tiav lub teeb pom kev zoo dua.
Tsim nyog qhov chaw laser yuav tsum raug xaiv kom tshem tawm qhov txo qis hauv qhov sib piv thiab SNR.
Piv nrog rau lwm cov kev yees duab uas twb muaj lawm, laser speckle contrast imaging muaj ntau qhov zoo. Nws tuaj yeem siv cov cuab yeej siv tau yooj yim thiab siv tau zoo los rov qab kho qhov kev daws teeb meem ntawm lub cev thiab lub cev. Thiab vim yog qhov muaj zog no, laser speckle qhov sib piv cov duab tau koom nrog hauv kev kos cov ntshav ntws rau ntau xyoo lawm. Kev siv LSCI tau txuas ntxiv mus rau ntau yam hauv kev kho mob biomedical uas suav nrog tab sis tsis txwv rau rheumatology, kub hnyiab, dermatology, neurology, kev phais plab hnyuv, kev kho hniav, kev tshawb fawb plawv. LSCI tuaj yeem raug coj mus rau lwm qhov yooj yim rau kev soj ntsuam tag nrho ntawm thaj chaw, ntsuas, thiab tshawb xyuas cov txheej txheem nyob hauv yuav luag lub sijhawm.
Transmissive-Detected Laser Speckle Imaging System rau Ntshav Flow Monitoring nyob rau hauv cov ntaub so ntswg tuab
Laser speckle contrast imaging (LSCI) yog lub cuab yeej muaj zog los saib xyuas cov ntshav ntws thiab tau siv dav hauv kev tshawb fawb ntawm microcirculation, ob qho tib si rau tsiaj thiab kev kho mob. Conventionally, LSCI feem ntau ua haujlwm ntawm kev pom kev pom kev. Txawm li cas los xij, nws tuaj yeem muab kev daws teeb meem rau lub cev thiab qhov chaw nyob rau hauv vivo daim ntawv thov tsuas yog nrog kev pab ntawm ntau lub qhov rais cov ntaub so ntswg, txwv tsis pub, qhov loj tshaj qhov zoo li qub speckle yuav txwv tsis pub nws qhov sib txawv thiab kev daws teeb meem. Ntawm no, peb tau tshawb xyuas qhov muaj peev xwm ntawm kev kuaj pom LSCI (TR-LSCI) rau kev saib xyuas cov ntshav hauv cov ntaub so ntswg tuab. Nws tau pom tias hom kev pom kev pom tau zoo dua thaum lub hom phiaj txheej nyob rau ntawm qhov chaw, tab sis cov duab zoo yuav txo qis nrog cov duab qhov tob, thaum lub transmissive-nrhiav hom tuaj yeem tau txais cov teeb liab muaj zog dua-rau-rov qab piv ( SBR) rau cov ntaub so ntswg tuab. Peb tau ua pov thawj ntxiv los ntawm cov ntaub so ntswg phantom, tsiaj txhu, thiab tib neeg kev sim uas nyob rau hauv ib qho tuab ntawm cov ntaub so ntswg, TR-LSCI tau pom zoo ua haujlwm zoo rau cov ntaub so ntswg tuab, thiab cov duab zoo yuav zoo dua yog tias siv cov wavelengths ntev dua ntawm ze- infrared teeb. Yog li ntawd, ob qho tib si theoretical thiab kev sim ua kom pom tau tias TR-LSCI muaj peev xwm tau txais cov ntaub ntawv ntawm cov ntaub so ntswg tuab thiab tuav lub peev xwm loj hauv kev tshawb fawb microcirculation.
Laser speckle contrast imaging (LSCI) yog qhov dav-teeb pom kev zoo, tsis muaj qhov tsis zoo nrog cov kev daws teeb meem ntawm lub cev thiab qhov chaw, uas yog raws li kev tsom xam ntawm lub teeb liab tom qab tawg thiab cuam tshuam, thiab yog li tau txais cov ntaub ntawv tshaj tawm ntawm cov khoom tawg hauv cov ntaub so ntswg. . Conventionally, nws ua hauj lwm nyob rau hauv lub reflective-nrhiav hom, thiab tau lug siv nyob rau hauv lub hauv paus kev tshawb fawb ntawm microcirculation uas nws dysfunction yog heev cuam tshuam rau ib tug series ntawm cov tsos mob, xws li ntshav qab zib, ischemic stroke, coronary heart disease thiab peripheral artery kab mob. Nrog kev phais-raws li lub qhov rais qhib pob txha taub hau, thinned-skull windows, thiab phais-dawb pob txha taub hau kho qhov muag clearing qhov rais, cortical ntshav txaus faib yuav tau pom meej pom siv cov pa reflective-nrhiav LSCI txheej txheem. Nrog rau lub qhov rais ntawm lub qhov rais thiab cov qhov rais kho qhov muag pom, LSCI cov lus pom zoo tuaj yeem muab cov ntshav ntws los ntawm tus kheej nrog kev daws teeb meem ntawm cov hlab ntsha. Txawm li cas los xij, yam tsis muaj "qhov rais", lub teeb yuav tsum nkag mus rau hauv cov ntaub so ntswg sab saud ntawm cov hlab ntsha sib sib zog nqus, thaum txoj kev nws tsis tu ncua, ua rau lub zog ntawm cov static speckle nyob rau hauv lub sab sauv txheej ntau dua li ntawm dynamic speckle teeb liab hauv lub sib sib zog nqus tsom txheej, ua rau qhov tsis tshua muaj qhov sib piv thiab kev daws teeb meem ntawm cov pa LSCI, lossis txawm tias ua rau cov ntshav ntws tsis pom. Tsis tas li ntawd, txawm tias muaj kev pab ntawm pob txha taub hau thiab cov qhov rais ntawm daim tawv nqaij, cov pa LSCI tseem tsuas muaj peev xwm muab kev daws teeb meem nyob rau hauv cov khaubncaws sab nraud povtseg, txawm tias lub cev ntawm cov nas feem ntau pua pua ntawm microns lossis millimeters tuab, ua rau nws tsis tshua muaj peev xwm tau txais. cov ntaub ntawv nthuav dav siv cov txheej txheem zoo li no.
Laser Speckle Imaging System yog ib qho tseem ceeb qhia txog txoj hauv kev kho mob
Muaj kev txaus siab ntxiv rau kev siv laser speckle contrast imaging (LSCI) ua ib qho cuab yeej rau kev ntsuam xyuas cov ntshav ntws hauv kev tshawb fawb ua ntej thiab kev siv tshuaj kho mob. LSCI siv cov ntaub so ntswg sib txawv los ntawm lub teeb pom kev zoo los muab cov txheej txheem yooj yim rau kev pom cov ncauj lus kom ntxaws spatiotemporal dynamics ntawm cov ntshav hloov pauv hauv lub sijhawm.
Laser speckle yog qhov kev cuam tshuam tsis sib xws uas tsim thaum lub teeb ci sib txawv los ntawm qhov nruab nrab uas tuaj yeem pom mus rau lub ntes xws li lub koob yees duab. Kev txav los ntawm cov khoom tawg, xws li cov qe ntshav liab hauv vasculature, ua rau muaj kev hloov pauv ntawm lub cev thiab lub cev ntawm cov qauv speckle. Speckle contrast tsom xam ntsuas qhov sib txawv hauv zos spatial variance, lossis qhov muag plooj, ntawm cov qauv speckle uas tshwm sim los ntawm cov ntshav ntws.
Hauv peb lub chaw kuaj mob, peb tsom mus rau kev ua haujlwm ntawm lub hlwb thiab siv LSCI los kawm txog cov hlab ntsha hlwb (CBF) dynamics. CBF yog ib qho tseem ceeb ntawm hemodynamic parameter nyob rau hauv lub hlwb uas yuav siv tau los kawm txog cov xwm txheej neurological xws li mob stroke, cortical kis kev nyuaj siab, thiab kev ua haujlwm ua haujlwm. Peb siv LSCI hauv cov qauv tsiaj ua ib lub cuab yeej kom nkag siab zoo dua cov txheej txheem neurophysiological tom qab cov xwm txheej no. Hauv tsev kho mob, LSCI tau siv zog ua cov cuab yeej tsis cuam tshuam rau kev phais mob neurosurgery uas tuaj yeem pab txo qis kev pheej hmoo ntawm ntshav qab zib tsis txaus.
Laser speckle contrast tsom xam (LASCA), tseem hu ua laser speckle contrast imaging (LSCI), yog ib txoj kev uas tam sim pom cov nqaij mos microcirculatory ntshav perfusion. Nws yog cov txheej txheem kev yees duab uas ua ke nrog kev daws teeb meem siab thiab kev kub ceev. Thaum ib yam khoom yog illuminated los ntawm lub teeb laser, lub backscattered lub teeb yuav tsim ib qho kev cuam tshuam cov qauv uas muaj xws li tsaus nti thiab kaj. Cov qauv no hu ua speckle pattern. Yog hais tias lub teeb pom kev zoo li qub, cov qauv speckle nyob ruaj khov. Thaum muaj kev txav mus los hauv cov khoom, xws li cov qe ntshav liab hauv cov ntaub so ntswg, cov qauv speckle yuav hloov lub sijhawm.
Peb lub Hoobkas
Guangzhou G-Cell Technology Co., Ltd. yog lub tuam txhab thev naus laus zis tshiab tsim los ntawm kev cia siab rau Tsinghua University Shenzhen Kawm Tiav Tsev Kawm Ntawv, Southern University of Science thiab Technology, thiab South China Normal University, thiab peb tsom mus rau daim ntawv thov ntawm optical imaging technology nyob rau hauv lub teb ntawm life sciences. Rau cov chav nyob hauv cov lus qhia txog kev thov, peb tuaj yeem muab koj cov khoom siv kho qhov muag pom kev thiab cov kev daws teeb meem. Peb muaj qhov ua tiav qhov kev sim kho qhov muag sim platform thiab ib pab pawg ntawm cov tub ntxhais hluas cov pob txha zoo. Raws li kev sib koom ua ke ntawm cov khoom siv hauv chav kuaj thiab kev lag luam hauv Is Taws Nem, lub tuam txhab tau cog lus los tsim lub cim tshiab ntawm cov khoom siv ntse ntse.
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