Multimodal Endoscopic Imaging System
Ib qho me me endoscope muaj peev xwm ntawm concurrently probing ntau qhov sib txawv mechanisms ntawm cov ntaub so ntswg nyob rau hauv siab daws teeb meem yog heev txaus nyiam, raws li nws ua rau nws muaj peev xwm muab complementary, ntau tiav cov ntaub so ntswg ntawm lub hauv nruab nrog cev nyuaj rau nkag tau. Ib qho kev sim ua kom pom tau tias qhov no multimodal endoscopic imaging system endoscope tsis yog tsuas yog muab cov kws phais mob nrog cov lus pom hauv lub sijhawm ntawm qhov chaw ntawm cov qog nqaij hlav thiab cov qog nqaij hlav qog nqaij hlav tab sis kuj tsim kom muaj kev paub zoo rau cov kws phais mob yam tsis muaj kev cuam tshuam kev phais.
Hauj lwm lawm
Tuam txhab Profile
Guangzhou G-Cell Technology Co., Ltd. yog lub tuam txhab thev naus laus zis tshiab tsim los ntawm kev cia siab rau Tsinghua University Shenzhen Graduate School, Southern University of Science thiab Technology, thiab South China Normal University, thiab peb tsom mus rau kev siv cov cuab yeej kho qhov muag hauv lub teb ntawm life sciences. Rau cov chav nyob hauv cov lus qhia txog kev thov, peb tuaj yeem muab koj cov khoom siv kho qhov muag pom kev thiab cov kev daws teeb meem. Peb muaj qhov ua tiav qhov kev sim kho qhov muag sim platform thiab ib pab pawg ntawm cov tub ntxhais hluas cov pob txha zoo. Raws li kev sib koom ua ke ntawm cov khoom siv hauv kev lag luam thiab kev lag luam hauv Is Taws Nem, lub tuam txhab tau cog lus los tsim ib tiam tshiab ntawm cov khoom siv ntse ntse hauv chav kuaj.
Vim Li Cas Xaiv Peb
Pab neeg ua haujlwm
Peb tshwj xeeb hauv kev siv cov cuab yeej kho qhov muag kho qhov muag rau thaj tsam ntawm cell biology. Rau kev tshawb fawb ntawm tes, kev soj ntsuam thiab lwm daim ntawv thov teb.Peb muaj qhov ua tiav kho qhov muag sim kev sim platform thiab ib pab pawg ntawm cov tub ntxhais hluas cov pob txha zoo.
Cov cuab yeej siv siab heev
Raws li kev sib koom ua ke ntawm cov khoom siv hauv kev lag luam thiab kev lag luam hauv Is Taws Nem, lub tuam txhab tau cog lus los tsim ib tiam tshiab ntawm cov khoom siv ntse ntse hauv chav kuaj.
Kev tshawb fawb ywj pheej thiab kev txhim kho
Raws li kev tsim kho tshiab ntawm pab pawg tshawb fawb thiab kev txhim kho muaj zog, GCell cov khoom lag luam tau txais kev ywj pheej tshawb fawb thiab kev tsim kho, kev tsim khoom ywj pheej, kev ywj pheej patents, thiab tau dhau ntau daim ntawv pov thawj xws li software monographs thiab cov qauv siv hluav taws xob patents.
Software zoo
Software tuning yog ua raws li kev siv tus cwj pwm ntawm cov neeg siv tshawb fawb tshawb fawb, thiab cov txiaj ntsig tau raug xa tawm raws li qhov xav tau ntawm cov ntawv tshawb fawb tshawb fawb thiab cov ntawv ceeb toom. Daim ntawv saib ua ntej cov ntaub ntawv tuaj yeem muab rov qab tau txhua lub sijhawm, thiab txhawb kev hloov pauv ntawm cov txiaj ntsig panoramic, uas yooj yim rau kev tshawb fawb thoob ntiaj teb.
Yam khoom
Tsiaj Me Me Hauv Vivo Imaging System
GCell Multimodal tsiaj me nyob rau hauv vivo imaging system yog ib tug tsiaj me hauv vivo imaging system uas siv ntau yam kev yees duab yees rau kev pom zoo, uas tuaj yeem tshawb xyuas thiab txheeb xyuas lub cev, kab mob, kev ua tau zoo thiab lwm yam ntaub ntawv ntawm cov tsiaj me. Cov thev naus laus zis no tuaj yeem txhim kho qhov raug thiab rhiab heev ntawm kev thaij duab, thiab muab cov ntaub ntawv nthuav dav thiab tob ntxiv rau kev tshawb fawb biomedical thiab kev tsim tshuaj.
Multimodal Endoscopic Imaging System
Photoacoustic multi-modal imaging system muab cov duab kho qhov muag thiab acoustic imaging cov tswv yim los muab cov duab daws teeb meem ntawm cov ntaub so ntswg ntawm qhov tob sib txawv. Cov thev naus laus zis no tuaj yeem siv rau ntau qhov chaw, xws li kev kuaj mob qog noj ntshav, kuaj lub hlwb, thiab kev kuaj ntshav vascular. Lub photoacoustic multi-modal imaging system muaj qhov zoo xws li tsis muaj kev cuam tshuam, kev ntsuas lub sijhawm tiag tiag, thiab tus nqi qis, uas ua rau nws muaj txiaj ntsig zoo rau kev tshawb fawb kho mob thiab kev siv tshuaj kho mob.
Dab tsi yog Multimodal Endoscopic Imaging System
Ib qho me me endoscope muaj peev xwm ntawm concurrently probing ntau qhov sib txawv mechanisms ntawm cov ntaub so ntswg nyob rau hauv siab daws teeb meem yog heev txaus nyiam, raws li nws ua rau nws muaj peev xwm muab complementary, ntau tiav cov ntaub so ntswg ntawm lub hauv nruab nrog cev nyuaj rau nkag tau. Ib qho kev sim ua kom pom tau tias qhov no multimodal endoscopic imaging system endoscope tsis yog tsuas yog muab cov kws phais mob nrog cov lus pom hauv lub sijhawm ntawm qhov chaw ntawm cov qog nqaij hlav thiab cov qog nqaij hlav qog nqaij hlav tab sis kuj tsim kom muaj kev paub zoo rau cov kws phais mob yam tsis muaj kev cuam tshuam kev phais.
Qhov zoo ntawm Multimodal Endoscopic Imaging System
Brightness yog ruaj khov thiab ceev ceev
Lub brightness ntawm lub koob yees duab endoscopic stabilizes sai. Thaum lub monitor pib, nws cia li pom qhov kub ntawm ib puag ncig los txiav txim siab qhov ci ci. Txawm li cas los xij, raws li qhov endoscope txuas ntxiv mus, nws cov kev daws teeb meem hloov pauv.
Cov txiaj ntsig zoo
Lub koob yees duab endoscopic muaj cov teebmeem zoo. Nws yog qhov zoo dua li lwm yam kev saib xyuas cov khoom siv hauv cov ntsiab lus ntawm cov xim xaum lossis iav qhov sib txawv pom. Nyob rau tib lub sijhawm, los ntawm kev hloov kho ntse ntawm saturation, nws tiv thaiv tib neeg lub qhov muag.
Qib siab ntawm cov teeb liab ua
Endoscopic monitor muaj qib siab ntawm cov teeb liab ua. Nws tuaj yeem kho qhov kev daws teeb meem ntawm cov pixels zoo tib yam kom cov duab pom tseeb dua. Nyob rau tib lub sijhawm, txawm tias nyob rau hauv ib puag ncig kev kho mob hnyav heev, lub ntsuas endoscopic tuaj yeem muab cov teeb meem tsis muaj teeb meem.
Kev pom dav dav
Lub koob yees duab endoscope muaj lub kaum sab xis pom dav, yog li cov duab tuaj yeem pom meej txawm tias saib ntawm sab xub ntiag lossis sab. Ntxiv mus, thaum saib los ntawm sab, yuav tsis muaj qhov nce ntawm chromatic aberration lossis qhov muag plooj vim muaj teeb meem ntawm lub kaum sab xis.
Prospective Multimodal Endoscopic imaging System Raws li kev yees duab yees rau kev kuaj mob qog
Peb tau tsim ib qho kev saib rau pem hauv ntej (FL) multimodal endoscopic system uas muaj xim, spectral cais, high-frequency ultrasound (HFUS) B-hom, thiab integrated backscattering coefficient (IBC) dluab rau kev kuaj mob qog nyob rau hauv qhov chaw. Kev kuaj mob qog nqaij hlav los ntawm qhov chaw ntawm txoj hnyuv mus rau sab hauv yog qhov tseem ceeb rau kev txiav txim siab txog kev kho mob qog noj ntshav. Piv txwv li, qhov submucosal ntxeem tau qhov tob ntawm cov qog ntxiv rau cov qog faib rau ntawm txoj hnyuv loj yog siv los ua qhov qhia txog seb qhov kev txiav txim siab endoscopic puas yuav ua haujlwm.
Yog li, peb tsim lub FL multimodal endoscopic system los muab cov ntaub ntawv ntawm cov qog faib tawm ntawm qhov chaw mus rau cov ntaub so ntswg sib sib zog nqus nrog cov neeg siab. Cov txheej txheem no tau raug soj ntsuam nrog bilayer gelatin phantoms uas muaj cov khoom sib txawv ntawm txhua txheej ntawm phantom nyob rau sab nraud. Tom qab ntsuas lub kaw lus nrog phantoms, nws tau ua haujlwm los ua tus cwj pwm plaub caug tib neeg txoj hnyuv tawm los ntawm cov neeg mob qog noj ntshav. Cov txheej txheem npaj tuaj yeem tso cai rau peb kom tau txais kev daws teeb meem tshuaj lom neeg, anatomical, thiab macro-molecular cov ntaub ntawv ntawm excised nyuv cov ntaub so ntswg nrog rau cov qog, yog li txhim kho qhov kev tshawb pom ntawm cov qog faib los ntawm qhov chaw mus rau cov ntaub so ntswg tob. Cov txiaj ntsig no qhia tau hais tias FL multimodal endoscopic system tuaj yeem yog ib qho kev tshuaj ntsuam xyuas tshiab rau cov qog nqaij hlav ntau yam.
Multimodality ntawm ib qho kev kho qhov muag pom tau hais tias siv ib lossis ntau qhov kev kho qhov muag los txhim kho qhov kev ua tau zoo tag nrho thiab kev siv ntau tshaj plaws. Peb ua qauv qhia ntau qhov system nrog oblique illumination uas ua ke ob txoj kev sib txawv; fluorescence micro-endoscopy thiab spectroscopy ib txhij thiab tuaj yeem siv tau kom tau txais cov ntaub ntawv sib txawv los ntawm tib qhov chaw ntawm cov qauv lom neeg. Hauv cov txheej txheem tam sim no, kev siv cov qhab nia ntsuas (GRIN) rod-lens ua rau nws muaj kev sib haum xeeb thiab oblique tshwm sim decouples illumination geometry nrog sau geometry, tiv thaiv CCD lub koob yees duab los ntawm saturation thiab txo cov naj npawb ntawm cov khoom siv kho qhov muag, yog li ua rau lub kaw lus txuas ntxiv me me thiab ua haujlwm tau yooj yim. Nws kuj overcomes qhov tsis zoo ntawm undesired reflections los ntawm txawv optical ntsiab.
Cov txiaj ntsig ntawm kev sim ib txhij thiab spectroscopy ntawm cov qauv lom neeg tau nthuav tawm nrog rau ntau qhov spectroscopic tsis; peak wavelength hloov, cheeb tsam hauv qab nkhaus thiab tag nrho qhov dav ib nrab siab tshaj plaws (FWHM). Tsis tas li ntawd, peb tau txais qhov hloov pauv liab rau cov qog nqaij hlav hauv qhov ncauj nrog rau cov ntaub so ntswg ntawm qhov ncauj 5.79 ± 1.071 nm. Qhov no tuaj yeem yog qhov taw qhia tseem ceeb rau kev kuaj mob qog noj ntshav hauv qhov ncauj.
Kev nce qib hauv cov duab taw qhia thev naus laus zis raws li Multimodal Endoscopic Imaging System Technology
Peb thov kom muaj ib lub tshuab endoscopic multimodal raws li lub teeb dawb (WL), multispectral (MS), thiab photometric stereo (PS) duab rau kev kuaj mob qog noj ntshav (CRC). Tsis ntev los no, kev txhim kho ntawm qhov tseeb ntawm CRC colonoscopy tau tshaj tawm.
Cov duab qhia thiab kev phais neeg hlau raws li endoscopic imaging technologies tuaj yeem txhim kho kev kho mob qog noj ntshav los ntawm kev tshem tawm tag nrho cov qog nqaij hlav cancer thiab zam kev puas tsuaj iatrogenic rau cov nqaij mos noj qab haus huv. Cov kws phais neeg soj ntsuam cov qog nqaij hlav ntawm tus nqi ntawm impeding phais workflow los yog ua hauj lwm nrog dimmed phais illumination, vim tam sim no endoscopic imaging systems tsis tau ib txhij thiab real-time xim thiab ze-infrared (NIR) fluorescence imaging nyob rau hauv ib txwm phais illumination.
Yuav kom kov yeej qhov teeb meem no, bio-inspired multimodal 3D endoscope combining cov yam ntxwv zoo heev ntawm tib neeg ob lub qhov muag thiab compound ob lub qhov muag ntawm mantis cw. Qhov no 3D endoscope, uas ua tiav ib txhij thiab lub sijhawm ua haujlwm ntawm peb-dimensional stereoscopic, xim, thiab NIR fluorescence, muaj peb ntu: ib qho dav-band binocular optical system zoo li tib neeg lub qhov muag, ib qho kev kho qhov muag relay, thiab multiband sensor. kev tshoov siab los ntawm mantis cws lub qhov muag. Los ntawm kev qhia txog qhov system optical relay, ob daim duab duab tom qab broad-band binocular optical system tuaj yeem npaj mus rau ib qho thiab tib lub multiband sensor.
Ib qho kev sim ua kom pom tau tias qhov no bio-inspired multimodal 3D endoscope tsis tsuas yog muab cov kws phais mob nrog cov lus pom zoo ntawm lub sijhawm ntawm qhov chaw ntawm cov qog nqaij hlav thiab cov qog nqaij hlav qog nqaij hlav tab sis kuj tsim kom muaj kev paub zoo rau cov kws phais mob yam tsis muaj kev cuam tshuam kev phais. Nws cov yam ntxwv zoo heev thiab zoo scalability tuaj yeem txhawb kev txhim kho ntxiv thiab kev siv cov duab qhia thiab kev phais neeg hlau.
Multimodal Endoscopic imaging Systems uas ua haujlwm tiag-lub sij hawm imaging ua lub luag haujlwm tseem ceeb hauv tshuaj
Feem ntau cov tshuab endoscope tsuas muaj ib qho kev ua haujlwm nkaus xwb thiab tseem muaj qhov ua tau zoo thiab tsis muaj kev xav tau rau ib txhij thiab lub sijhawm tiag tiag multimodal imaging ntawm peb-dimensional stereoscopic, multispectral, thiab txawm polarization. Tshwj xeeb, ib txhij thiab lub sijhawm tiag tiag 3D duab ntawm ob qho tib si xim thiab NIR fluorescence yog qhov tsim nyog rau kev ua haujlwm pom thiab qhov chaw ntawm cov qog nqaij hlav, cov qog nqaij hlav, thiab cov qauv tseem ceeb yam tsis muaj kev cuam tshuam kev phais. Feem ntau NIR fluorescence endoscopes ua haujlwm nrog qhov muag pom kev phais, uas cuam tshuam rau kev phais kev ua haujlwm: cov kws phais neeg ua haujlwm nres, tua lossis dim lub teeb dawb, saib cov qog nqaij hlav nrog NIR instrumentation, thiab tom qab ntawd txuas ntxiv kev phais raws li pom qhov pom tsis muaj NIR fluorescence duab. kev taw qhia los yog dim illumination.
Ntawm no, peb pom tau tias bio-inspired multimodal 3D endoscope nrog ib txhij thiab real-time 3D duab ntawm ob qho tib si xim thiab NIR fluorescence tuaj yeem tsim los ntawm kev sib txuas cov yam ntxwv zoo ntawm tib neeg lub qhov muag thiab qhov muag ntawm mantis cw. Ntau hom ob lub qhov muag tau tsim nyob rau hauv qhov xwm txheej tom qab 500 lab xyoo ntawm evolution. Ntau lub tshuab pom kev pom thiab cov khoom siv, xws li xim-polarization sensor, hemispherical electronic eye camera, compound eye cameras, eagle eye koob yees duab, tau txais kev tshoov siab los ntawm kev pom kev lom neeg.
Lub sijhawm no, ntau cov thev naus laus zis tau thov rau 3D duab, xws li suav tomography (CT), sib nqus resonance imaging (MRI), optical coherence tomography (OCT), teeb pom kev zoo, lub sijhawm ya davhlau (TOF), binocular imaging, thiab lub teeb pom kev zoo. . Ntawm lawv, cov duab kos duab binocular tau tshwm sim los ntawm tib neeg lub qhov muag tuaj yeem tsim kev paub zoo rau cov kws phais, ua rau nws muaj txiaj ntsig zoo rau kev phais cov duab qhia kev phais lossis kev phais neeg hlau.
Multimodal Endoscopic Imaging System Ua kom pom tseeb dua
Kev tsom xam tam sim no ntawm hluav taws xob endoscopy yog nyob rau ntawm morphology thiab cov qauv zoo ntawm cov mucosal nto, thiab tsis muaj kev soj ntsuam zoo rau cov qauv sib sib zog nqus ntawm cov mucosa thiab kev ua haujlwm ntawm cov ntshav oxygen binding. Txawm li cas los xij, multilayer morphology thiab kev ua haujlwm ntawm cov hlab ntsha mucosal nyob rau hauv cov xwm txheej sib txawv ntawm kev zom zaub mov yuav tsum sib txawv. Yog li ntawd, peb npaj ib txoj kev ntawm endoscopic multimodal functional imaging rau cov pa endoscopic kev soj ntsuam xyuas cov mucosa ntawm lub digestive ib ntsuj av, uas yog raws li nyob rau hauv uas twb muaj lawm electronic endoscope, laser speckle contrast imaging thiab multispectral ntshav oxygen imaging technology.
Laser irradiation tau muab rau kom tau txais cov ntaub ntawv ntawm coherent lub teeb nyob rau hauv lub mucosal nto thiab sib sib zog nqus tawg ntawm lub teeb coherent kom tau txais cov ntaub ntawv ntau theem vascular tis, thiab multispectral irradiation imaging tau nqa tawm kom tau cov pa oxygenation ntawm lub mucosa. Thaum kawg, peb tuaj yeem pom qhov sib txawv ntawm cov duab ntawm cov hlab ntsha sib sib zog nqus ntawm cov kab mob hauv plab, uas tuaj yeem pab peb txhawm rau kuaj xyuas ntxov ntawm cov qog nqaij hlav hauv plab tsis ua haujlwm.
Raws li ntau qhov kev sojntsuam yuav tsum tau ua, kev sojntsuam rov qab mus rau cov hlab ntsha yuav tsum tau ua, thiab cov nqi cuam tshuam (xws li, coj cov xov hlau, ua kom tsis muaj menyuam, thiab lwm yam) kuj nce ntxiv. Tsis tas li ntawd, txij li cov ntaub ntawv tau txais los ntawm ib tus zuj zus, cov duab kos npe yog tsim nyog, uas feem ntau ua off-line manually lossis semi-automatically. Tsis tsuas yog cov duab kos npe yog ib qho kev ua haujlwm nyuaj thiab siv sijhawm, nws tseem muaj qhov raug txwv vim yog tib neeg yuam kev thiab interobserver variances. Yog li ntawd, ib qho txheej txheem uas tuaj yeem ua tiav ib txhij ua ntau yam kev yees duab los ntawm ib qho kev sojntsuam ib leeg yuav ua kom cov txiaj ntsig tau zoo hauv kev siv tshuaj kho mob.
Ntawm no, peb nthuav tawm ntau hom kev tshuaj ntsuam xyuas ntau yam rau kev kho plawv thiab mob plab. Hauv vivo thiab ex vivo kev tshawb fawb siv luav thiab nas tau ua rau kev siv lub cev. Cov txiaj ntsig tau pom tias kev siv tshuab multimodal muaj peev xwm kov yeej cov kev txwv ntawm tus kheej intravascular imaging modality, muab cov ntaub ntawv ntau ntxiv ntawm morphology thiab / lossis muaj pes tsawg leeg rau tus cwj pwm zoo dua.
Peb tawm tswv yim endoscopic duab mosaicking algorithm uas muaj zog rau lub teeb txias hloov, specular reflections, thiab feature-tsawg scenes. Cov xwm txheej no tshwj xeeb tshaj yog nyob rau hauv qhov kev phais me me uas lub teeb txav txav nrog lub koob yees duab kom pom qhov chaw nyob ze. Qhov no ua rau nws nyuaj rau ib txoj kev sau npe rau ib daim duab kom taug qab lub koob yees duab suab thiab tom qab ntawd tsim cov mosaics zoo ib yam ntawm qhov chaw phais mob nthuav dav thoob plaws qhov chaw sib txawv thiab sib txawv. Es tsis txhob cia siab rau ib qho tshwj xeeb feature extractor los yog cov duab sau npe txoj kev, peb thov kom fuse sib txawv cov duab sau npe algorithms raws li lawv tsis paub tseeb, tsim qhov teeb meem raws li affine pose graph optimisation. Qhov no tso cai los muab cov duab sib txuas, kev sau npe tsis muaj nqis, thiab kev kawm cov kev kawm hauv ib lub moj khaum.
Txhawm rau ua kom pom peb daim ntawv thov peb xav txog kev kawm sib sib zog nqus-raws li optical flow, tes-crafted nta, thiab kev siv-raws li kev sau npe, txawm li cas los xij, lub moj khaum yog qhov dav dav thiab tuaj yeem siv los ua lwm qhov chaw ntawm kev kwv yees, suav nrog lwm yam kev hloov pauv. Peb lees paub qhov kev ua tau zoo ntawm peb txoj hauv kev ntawm peb cov ntaub ntawv sib txawv nrog cov yam ntxwv sib txawv los qhia txog nws txoj kev muaj peev xwm dav dav, ua kom pom qhov zoo ntawm peb cov phiaj xwm fusion. Thaum txhua tus neeg sau npe algorithm thaum kawg ua tsis tiav ntawm qee qhov kev phais mob, txoj hauv kev fusion yooj yim txiav txim siab seb cov algorithms siv thiab qhov twg feem ntau kom tau txais cov mosaic zoo ib yam.
Peb lub Hoobkas
Guangzhou G-Cell Technology Co., Ltd. yog lub tuam txhab thev naus laus zis tshiab tsim los ntawm kev cia siab rau Tsinghua University Shenzhen Graduate School, Southern University of Science thiab Technology, thiab South China Normal University, thiab peb tsom mus rau kev siv cov cuab yeej kho qhov muag hauv lub teb ntawm life sciences. Rau cov chav nyob hauv cov lus qhia txog kev thov, peb tuaj yeem muab koj cov khoom siv kho qhov muag pom kev thiab cov kev daws teeb meem. Peb muaj qhov ua tiav qhov kev sim kho qhov muag sim platform thiab ib pab pawg ntawm cov tub ntxhais hluas cov pob txha zoo. Raws li kev sib koom ua ke ntawm cov khoom siv hauv kev lag luam thiab kev lag luam hauv Is Taws Nem, lub tuam txhab tau cog lus los tsim ib tiam tshiab ntawm cov khoom siv ntse ntse hauv chav kuaj.
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