Tsiaj Me me hauv Vivo Imaging System
Cov tsiaj me hauv vivo imaging system tau dhau los ua qhov tseem ceeb rau cov kws tshawb fawb thaum lawv txuas ntxiv tshawb fawb cov kab mob thiab cov txheej txheem physiological los ntawm kev tshawb fawb preclinical. Txoj kev ntsuas no feem ntau yog siv rau hauv kev tshawb fawb biomedical vim nws tsis muaj kev cuam tshuam thiab tsim cov duab siab ntawm cov ntaub so ntswg, kabmob, thiab cov txheej txheem hauv cov tsiaj nyob hauv cov qib molecular thiab cellular. Hauv vivo imaging ua lub luag haujlwm tseem ceeb hauv kev tsim cov tshuaj tshiab thiab kev kho mob thiab tshuaj xyuas lawv cov teebmeem ntawm lawv qhov kev xeem.
Hauj lwm lawm
Tuam txhab Profile
Guangzhou G-Cell Technology Co., Ltd. yog lub tuam txhab thev naus laus zis tshiab tsim los ntawm kev cia siab rau Tsinghua University Shenzhen Graduate School, Southern University of Science thiab Technology, thiab South China Normal University, thiab peb tsom mus rau kev siv cov cuab yeej kho qhov muag hauv lub teb ntawm life sciences. Rau cov chav nyob hauv cov lus qhia txog kev thov, peb tuaj yeem muab koj cov khoom siv kho qhov muag pom kev thiab cov kev daws teeb meem. Peb muaj qhov ua tiav kev sim kho qhov muag qhov chaw sim thiab ib pawg ntawm cov tub ntxhais hluas cov pob txha zoo. Raws li kev sib koom ua ke ntawm cov khoom siv hauv kev lag luam thiab kev lag luam hauv Is Taws Nem, lub tuam txhab tau cog lus los tsim ib tiam tshiab ntawm cov khoom siv ntse ntse hauv chav kuaj.
Vim Li Cas Xaiv Peb
Pab neeg ua haujlwm
Peb tshwj xeeb hauv kev siv cov cuab yeej kho qhov muag kho qhov muag rau thaj tsam ntawm cell biology. Rau kev tshawb fawb ntawm tes, kev soj ntsuam thiab lwm daim ntawv thov teb.Peb muaj qhov ua tiav kev sim kho qhov muag sim platform thiab ib pawg ntawm cov tub ntxhais hluas cov pob txha zoo tshaj plaws.
Cov cuab yeej siv siab heev
Raws li kev sib koom ua ke ntawm cov khoom siv hauv kev lag luam thiab kev lag luam hauv Is Taws Nem, lub tuam txhab tau cog lus los tsim ib tiam tshiab ntawm cov khoom siv ntse ntse hauv chav kuaj.
Kev tshawb fawb ywj pheej thiab kev txhim kho
Raws li kev tsim kho tshiab ntawm pab pawg tshawb fawb thiab kev txhim kho muaj zog, GCell cov khoom lag luam tau txais kev ywj pheej tshawb fawb thiab kev tsim kho, kev tsim khoom ywj pheej, kev ywj pheej patents, thiab tau dhau ntau daim ntawv pov thawj xws li software monographs thiab cov qauv siv hluav taws xob patents.
Software zoo
Software tuning yog nqa tawm raws li kev siv tus cwj pwm ntawm cov neeg siv tshawb fawb tshawb fawb, thiab cov txiaj ntsig tau raug xa tawm raws li qhov xav tau ntawm cov ntawv tshawb fawb tshawb fawb thiab cov ntawv ceeb toom. Daim ntawv saib ua ntej cov ntaub ntawv tuaj yeem muab rov qab tau txhua lub sijhawm, thiab kev txhawb nqa kev hloov pauv ntawm cov txiaj ntsig panoramic, uas yooj yim rau kev tshawb fawb thoob ntiaj teb.
Yam khoom
Multimodal Endoscopic Imaging System
Photoacoustic multi-modal imaging system muab cov duab kho qhov muag thiab acoustic imaging cov tswv yim los muab cov duab daws teeb meem ntawm cov ntaub so ntswg ntawm qhov tob sib txawv. Cov thev naus laus zis no tuaj yeem siv rau ntau qhov chaw, xws li kev kuaj mob qog noj ntshav, kuaj lub hlwb, thiab kev kuaj ntshav vascular. Lub photoacoustic multi-modal imaging system muaj qhov zoo xws li tsis muaj kev cuam tshuam, kev ntsuas lub sijhawm tiag tiag, thiab tus nqi qis, uas ua rau nws muaj txiaj ntsig zoo rau kev tshawb fawb kho mob thiab kev siv tshuaj kho mob.
Tsiaj Me Me Hauv Vivo Imaging System
GCell Multimodal tsiaj me nyob rau hauv vivo imaging system yog ib tug tsiaj me hauv vivo imaging system uas siv ntau yam kev yees duab yees rau kev pom zoo, uas tuaj yeem tshawb xyuas thiab txheeb xyuas lub cev, kab mob, kev ua tau zoo thiab lwm yam ntaub ntawv ntawm cov tsiaj me. Cov thev naus laus zis no tuaj yeem txhim kho qhov raug thiab rhiab heev ntawm kev thaij duab, thiab muab cov ntaub ntawv nthuav dav thiab tob ntxiv rau kev tshawb fawb biomedical thiab kev tsim tshuaj.
Dab Tsi Yog Tsiaj Me Hauv Vivo Imaging System
Cov tsiaj me hauv vivo imaging system tau dhau los ua qhov tseem ceeb rau cov kws tshawb fawb thaum lawv txuas ntxiv tshawb fawb cov kab mob thiab cov txheej txheem physiological los ntawm kev tshawb fawb preclinical. Txoj kev ntsuas no feem ntau yog siv rau hauv kev tshawb fawb biomedical vim nws tsis muaj kev cuam tshuam thiab tsim cov duab siab ntawm cov ntaub so ntswg, kabmob, thiab cov txheej txheem hauv cov tsiaj nyob hauv cov qib molecular thiab cellular. Hauv vivo imaging ua lub luag haujlwm tseem ceeb hauv kev tsim cov tshuaj tshiab thiab kev kho mob thiab tshuaj xyuas lawv cov teebmeem ntawm lawv qhov kev xeem.
Qhov zoo ntawm Cov Tsiaj Me Me Hauv Vivo Imaging System
Qhov siab tshaj plaws optical imaging rhiab heev
Cov duab thaij duab muab qhov siab tshaj plaws optical imaging rhiab heev tam sim no ntawm kev ua lag luam. Qhov no tso siab rau kev ua haujlwm siab kho vajtse teeb tsa, lub koob yees duab zoo obscura thiab cov tshuab lim hloov ceev ceev.
Cov tshuaj fluorescence muaj zog tshaj plaws
Thaum lub sij hawm tus txheej txheem ntawm vivo fluorescence imaging ntawm cov tsiaj me hauv vivo imaging system, cov tsiaj me yuav tsis tsuas excite txaus cov cim qhia tab sis kuj tsim ib tug loj tus naj npawb ntawm autofluorescence signals. Tus yuam sij rau fluorescence imaging yog tias lub kaw lus ntes thiab txheeb xyuas cov cim muaj zog txaus los ntawm cov teeb liab autofluorescence. Yog li ntawd, lub teeb liab-rau-lub suab piv tau dhau los ua qhov tseem ceeb hauv kev ntsuas qhov zoo ntawm fluorescence imaging.
Fluorescence molecular tomography
Cov tsiaj me hauv vivo imaging system tuaj yeem ua ntau qhov kev txheeb xyuas los ntawm cov hauv qab kis lub teeb kom tau txais hauv vivo fluorescence molecular tomographic duab cov ntaub ntawv, thaum txhim kho cov duab teeb liab-rau-suab nrov piv.
Patented spectral sib cais tshuab
Nyob rau hauv lub hauv paus ntawm tau nruab nrog txaus nqaim-bandwidth thiab high-transmittance lim, ib tug complex thiab scientific spectral sib cais algorithm yog lub core technology rau tshem tawm autofluorescence ntawm cov tsiaj me thiab txheeb xyuas ntau xim fluorescence.
Tsiaj Me Me Hauv Vivo Imaging Systems yog lub hauv paus rau ntau yam kev kho mob
Me-tsiaj imaging yog ib qho cuab yeej tseem ceeb los tshawb xyuas cov tshuaj tshiab thiab siv tau lawv lub peev xwm hauv vivo. CT thiab MRI yog txoj hauv kev zoo rau kev kuaj mob anatomical thiab kev ua haujlwm, tab sis tsis tuaj yeem siv tau rau kev kuaj pom molecular vim lawv xav tau cov tshuaj muaj txiaj ntsig zoo ntawm cov tshuaj. Txoj kev kho qhov muag ntawm cov duab tuaj yeem ua tiav ntawm qib tracer siv bioluminescence thiab fluorescent imaging cov tswv yim, tab sis lawv tsuas tuaj yeem tawm cov duab kos duab uas tsis tuaj yeem muab cov ntaub ntawv ntau. Cov duab tsiaj me me nrog PET thiab SPECT tso cai rau kev kawm tsis muaj kev cuam tshuam ntawm cov tshuaj tshiab nrog rau lawv cov teebmeem hauv cov tsiaj nyob rau ntau lub sijhawm. Cov txheej txheem yog xa ncaj qha mus rau hauv tsev kho mob thiab muab txoj hauv kev sai thiab raug nqi los tsim cov tswv yim kho tshiab.
Kev kos duab tsiaj me muaj ntau yam zoo: kev tshawb fawb ntev hauv tib tsiaj, muaj peev xwm ua kom pom kev tsis pom kev ntawm lub cev thiab lub cev hloov pauv, ntau qhov sib txawv ntawm cov duab, muaj peev xwm sau tau cov ntaub ntawv peb-dimensional tag nrho, thiab muaj peev xwm sib txuas cov duab los ntawm ntau qhov kev pom zoo.
Qhov tshwj xeeb ntawm cov tsiaj me me los ntawm kev daws teeb meem siab PET nthuav qhia lub physics ntawm gas chamber detection thiab lub peev xwm reemergence ntawm gas detector systems rau cov tsiaj me me ntawm 1 mm daws teeb meem nrog rau cov ntaub ntawv tsim nyog rau lwm cov tsiaj imaging systems, xws li PET / CT thiab PET /MRI. Thaum cov tsiaj loj dua tau kawm txog tib neeg cov duab kos duab, cov cuab yeej siv duab zoo siab nrog cov kev daws teeb meem nyob rau hauv thaj tsam ntawm millimeters thiab hauv qab no yog xav tau rau cov tsiaj me xws li nas thiab nas. PET thev naus laus zis ntawm tshooj no yog ua raws li cov khoom siv sib npaug sib npaug (MWPC) cov khoom siv. Cov ntsiab lus tseem ceeb ntawm kev siv cov qauv tsiaj yuav raug tham, thiab cov kev siv tshwj xeeb ntawm cov tsiaj me me hauv kev kuaj mob plawv, oncological, thiab cov kab mob neurological yog cov piv txwv tseem ceeb.
Cov kev siv zog zoo kawg nkaus uas tau ua los ntawm cov thev naus laus zis molecular duab qhia tau tias nws muaj peev xwm tseem ceeb thiab ntau yam kev siv. Lub cim ntawm cov kab mob tshwj xeeb tsiaj cov qauv, thiab kev txhim kho ntawm cov phiaj xwm tshwj xeeb probes thiab cov neeg sau xov xwm genetic encoded yog lwm qhov tseem ceeb. Kev txhim kho txuas ntxiv hauv kev ntsuas, kev txheeb xyuas cov hom phiaj tshiab thiab cov noob caj noob ces, thiab muaj kev txhim kho cov duab sojntsuam yuav tsum tau ua. Multimodal imaging probes yuav tsum muab kev hloov pauv yooj yim ntawm kev tshawb fawb hauv chav kuaj, suav nrog kev tshawb fawb tsiaj me thiab kev siv tshuaj kho mob. Ntawm no, peb tau tshuaj xyuas cov tswv yim tseem ceeb ntawm kev tsis pom kev hauv vivo imaging txoj kev hauv cov tsiaj me los qhia txog lub tswv yim ntawm molecular imaging.
Kev nce qib hauv cov duab molecular tsis ntev los no tso cai rau peb pom ob qho tib si cellular thiab subcellular txheej txheem nyob rau hauv cov kev kawm nyob rau theem molecular thiab nyob rau theem anatomical. Molecular imaging yog moleculargenetic imaging rau visualizing cellular txheej txheem los ntawm kev sib xyaw ntawm molecular biology thiab biomedical imaging. Cov txheej txheem zoo kawg no muab kev tshawb fawb tsis yog tsuas yog hauv molecular cell biology tab sis kuj nyob rau hauv lwm yam. Kev txhim kho zoo kawg nkaus ntawm cov duab molecular tau ua tiav hauv kev pom, kev ua yam ntxwv, thiab kev ua kom muaj nuj nqis ntawm cov txheej txheem biologic los ntawm kev sib koom ua ke ntawm ntau yam sib txawv xws li noob caj noob ces, pharmacology, chemistry, physics, engineering, thiab tshuaj. Hauv particular, kev txhim kho ntawm kev tswj cov noob xa thiab cov noob qhia vector tshuab txhawb kev tsim ntau yam ntawm cov neeg sau xov xwm cov noob rau kev pom, piv txwv li, chloramphenicol acetyltransferase, b-galactosidase, luciferases, thiab fluorescent proteins.
Conventionally, ib tug recombinant plasmid, uas muaj lub hom phiaj gene thiab ib tug reporter gene, tau siv los saib xyuas lub hom phiaj gene qhia los ntawm assaying reporter gene qhia. Txawm li cas los xij, txoj kev no tsis tuaj yeem siv ncaj qha rau cov tsiaj muaj sia vim tias qhov sib txawv ntawm lub teeb tsis sib xws los ntawm cov neeg sau xov xwm cov protein tsis txaus los pom hauv cov tsiaj rau cov duab uas tsis muaj kev cuam tshuam. Cov tswv yim sib txawv yog xav tau rau kev saib xyuas cov noob qhia hauv vivo imaging. Kev sib sau ntawm cov teeb liab tshwj xeeb rau kev nthuav dav nws qhov kev siv zog ua rau nws tuaj yeem pom qhov chaw hauv cheeb tsam, kom muaj nuj nqis, thiab rov ua dua kev txiav txim siab ntawm cov noob qhia hauv vivo noninvasive imaging. Cov tswv yim zoo dua tau raug sim kom kov yeej cov teeb meem rau kev saib xyuas cov noob qhia hauv vivo los ntawm kev nrhiav txoj hauv kev los ntawm xov tooj cua-pharmaceutics thiab physics. Radiolabeled me me tebchaw thiab paramagnetic probes tau tsim los rau kev ntsuam xyuas cov proteins thiab magnetic signals, accelerating non-invasive molecular imaging technology.
Technology Development Methods of Me Tsiaj Hauv Vivo Imaging System
Txoj kev loj hlob ntawm molecular imaging technologies tau ua kom yooj yim los ntawm kev txhim kho ntawm cov cuab yeej siv duab nrog rau cov khoom siv duab xws li cov khoom siv txhim kho, kev sojntsuam, ligands, thiab cov neeg sau xov xwm tsim. Cov qauv tsiaj me muaj txiaj ntsig zoo hauv kev tshawb fawb txog kab mob uas nyuaj lossis ua tsis tau rau tib neeg. Kev soj ntsuam rov qab yog qhov tsim nyog ntawm kev thaij duab tsiaj me me uas tsis muaj kev cuam tshuam, uas muab cov ntaub ntawv hais txog qhov ntev thiab lub cev ntawm tus kab mob hauv kev loj hlob thiab kev loj hlob. Muaj ntau yam kev kuaj pom, suav nrog micro-computed tomography (CT), micro-single photon emission computed tomography (SPECT), micro-positron emission tomography (PET), micro-magnetic resonance imaging (MRI), micro-ultrasonography (US), thiab Ntau yam kev kho qhov muag siv cov fluorescence thiab bioluminescence, muaj rau cov tsiaj me me.
Tsis ntev los no, qhov kev daws teeb meem ntawm qee qhov kev ntsuas kev ntsuas tau nce mus txog qib cellular, thiab kev nce qib hauv kev siv thev naus laus zis tau ua rau kev tsim cov duab sib xyaw ua ke, xws li PET / CT, SPECT / CT, thiab PET / MRI. Siv cov cuab yeej tshiab tsim kho kev sib koom ua ke, cov ntaub ntawv qhia meej hauv cheeb tsam ntawm ob qho tib si anatomic thiab molecular kev ua haujlwm tuaj yeem tau txais hauv ib qho kev sib tham. Qhov zoo ntawm multimodal mus kom ze rau molecular imaging muab cov duab zoo dua rau kev pom cov cellular, haumxeeb, thiab morphologic hloov. Molecular thiab genetic hloov feem ntau ua ntej biochemical, physiologic, thiab anatomic hloov. Cov kev hloov pauv ntawm lub cev tuaj yeem pom tau los ntawm cov qauv kev pom zoo xws li CT, MRI, US, thiab radiography. Kev hloov pauv biochemical thiab lub cev muaj zog tuaj yeem saib xyuas los ntawm kev siv PET, SPECT, thiab MRI kev siv zog. Molecular genetic imaging muaj ntau yam kev xaiv hauv kev pom kev hloov pauv caj ces molecular, uas yog tshwm sim thaum pib ntawm feem ntau cov kab mob. Cov tswv yim rau kev saib xyuas cov noob qhia hauv cov tsiaj me me molecular imaging yog dav txhais tau tias yog direct thiab indirect imaging.
Cov Tsiaj Me Me Hauv Vivo Imaging System Ua Cov Duab Ntsuam Xyuas yooj yim dua thiab ntau tus qauv
Ntau cov cuab yeej tsim-xws li tsim tshwj xeeb rau hauv vivo imaging, lossis siv cov thev naus laus zis los ntawm lwm cov duab kos duab zoo li cov ntaub ntawv gel-yog tseem ua haujlwm, thiab hauv cov no, ntau tus neeg pom zoo, tau nce ntxiv tab sis tej zaum tsis yog kev hloov kho tshiab. Cov tsiaj me hauv vivo imaging systems yuav conceptually muab faib ua ob qhov chaw: thawj yog cov instrumentation-lub teeb-nruj lub thawv, lub teeb-sensing hardware, thiab cov duab ua thiab nrhiav software txuam nrog nws.
Optical imaging tau raws txoj kev tau txais txiaj ntsig los ntawm ntau lub koob yees duab rhiab, ua haujlwm ntau dua thiab muaj peev xwm khaws cov ntaub ntawv, thiab ntau dua algorithms. Kev sib raug zoo nrog rau lwm yam kev ntsuas kev ntsuas-los ntawm kev siv cov khoom siv sib xws, lossis kev thauj mus los ntawm cov twj paj nruag uas tso cai rau kev sib koom ua ke ntawm cov cim kos npe, piv txwv li- tau ua yooj yim dua, thiab qee zaus seamless, tso cai rau cov ntaub ntawv ntxiv kom tau txais los ntawm tib cov tsiaj ib txhij. los yog dhau sijhawm. Versions ntawm peb qhov dimension, qee zaum muaj teeb meem, tau qhia thiab puag, tso cai rau lub teeb pom kev tob thiab lub zog kom zoo dua kwv yees.
Ib-nias xaiv ntawm cov cheeb tsam-ntawm-kev txaus siab (ROI) nyob rau hauv cov duab software platforms ua rau kev tsom xam ntawm cov duab yooj yim dua thiab ntau tus qauv. Tsis tas li ntawd, qee lub tshuab tso cai rau tus neeg siv xaiv seb cov ntaub ntawv puas rov qab los yog ua tiav ua ntej kev soj ntsuam, nrog rau keeb kwm yav dhau los tshem tawm, suab nrov txo, lossis lwm yam kev suav ua cov duab ua rau lawv.Peb muaj cov tshuab nrog kev ua haujlwm ntev optics kom tso cai rau microscopic. interrogation ntawm cov qog nyob rau hauv daim tawv nqaij flaps, piv txwv li.
Tsiaj Me Me Hauv Vivo Imaging System tuaj yeem soj ntsuam cov qauv sab hauv hauv lub sijhawm tiag tiag
Txawm hais tias kev siv cov tsiaj me rau hauv vivo kev sim tau nthuav dav, tsuas yog tsis ntev los no tau muaj cov tswv yim yooj yim uas tso cai rau tsis muaj kev cuam tshuam hauv vivo imaging ntawm cov tsiaj me. Vim tias cov tswv yim no tso cai rau tib tus tib neeg cov ncauj lus kom ua raws li qhov ntev ntawm lub sijhawm ntawm kev sim, lawv txoj kev siv tau hloov pauv sai sai ntawm cov tsiaj me ua haujlwm hauv chav kuaj. Peb tsom mus rau rau 6 qhov kev kuaj pom uas tau nce ntxiv rau cov tsiaj me hauv vivo imaging: optical imaging (OI), magnetic resonance imaging (MRI), xam tomography (CT), ib leeg-photon emission tomography (SPECT), ultrasound (US), thiab positron-emission tomography (PET). Txhua qhov kev hloov pauv tso cai rau kev taug qab tsis muaj zog ntawm cov hlwb thiab cov khoom lag luam ntawm tes hauv vivo. Tsis tas li ntawd, multimodality imaging, combining ob los yog ntau tshaj ntawm cov tswv yim no, kuj tau nce ua hauj lwm los mus kov yeej cov kev txwv ntawm txhua txoj kev ywj pheej.
Kev nce qib tsis ntev los no hauv molecular biology tau nthuav dav lub hom phiaj ntawm kev tshawb fawb hauv chav kuaj los ntawm kev ua haujlwm hauv vitro mus rau lub sijhawm tiag tiag hauv vivo soj ntsuam cov txheej txheem ntawm tes thiab cov qauv hloov pauv hauv cov ntaub so ntswg. Txawm hais tias muaj kev siv cov tsiaj me kom ua tiav cov hom phiaj no, txog niaj hnub no feem ntau hauv vivo thwmsim tau koom nrog ntau lub chaw kuaj tsiaj uas tau sau tseg txhua lub sijhawm hauv qhov kev sim ntev. Kev soj ntsuam ntawm cov ntaub so ntswg lossis cov noob caj noob ces tau raug siv los tsim ntau cov txiaj ntsig zoo li qub, uas ua ke yog siv los ua kev txiav txim siab txog cov txheej txheem dynamic hloov lub sijhawm. Nyob rau hauv qhov sib piv, ntau lub tswv yim tshiab tam sim no tso cai rau cov duab tsis zoo-anatomical lossis molecular visualization yam tsis tas yuav sau lossis txiav tawm-ntawm cov tsiaj me, tso cai rau cov neeg tshawb xyuas qhov ua tau kom ua tiav cov kev ntsuas dynamic hauv tib tsiaj ua raws li nyob rau lub sijhawm ntawm kev kawm ntev.
Ntawm no, peb tshuaj xyuas ntau lub thev naus laus zis tam sim no tau siv ntau ntxiv rau kev kuaj pom tsis zoo ntawm cov tsiaj me: kho qhov muag (OI), suav nrog ob lub cev tag nrho thiab ob-photon intravital imaging, magnetic resonance imaging (MRI), xam tomography (CT), positron- emission tomography (PET), ib leeg-photon emission tomography (SPECT), thiab ultrasound (US). Peb piav qhia qhov ua tau zoo thiab qhov tsis muaj zog ntawm cov qauv no thiab qhia txog lub sijhawm rau kev ua duab multimodal, qhov twg ob lossis ntau qhov qauv sib xyaw ua ke kom kov yeej cov kev txwv ntawm txhua tus neeg siv thev naus laus zis txhawm rau ua kom muaj txiaj ntsig kev sim ntau tshaj plaws.
Peb lub Hoobkas
Guangzhou G-Cell Technology Co., Ltd. yog lub tuam txhab thev naus laus zis tshiab tsim los ntawm kev cia siab rau Tsinghua University Shenzhen Graduate School, Southern University of Science thiab Technology, thiab South China Normal University, thiab peb tsom mus rau kev siv cov cuab yeej kho qhov muag hauv lub teb ntawm life sciences. Rau cov chav nyob hauv cov lus qhia txog kev thov, peb tuaj yeem muab koj cov khoom siv kho qhov muag pom kev thiab cov kev daws teeb meem. Peb muaj qhov ua tiav kev sim kho qhov muag qhov chaw sim thiab ib pawg ntawm cov tub ntxhais hluas cov pob txha zoo. Raws li kev sib koom ua ke ntawm cov khoom siv hauv kev lag luam thiab kev lag luam hauv Is Taws Nem, lub tuam txhab tau cog lus los tsim ib tiam tshiab ntawm cov khoom siv ntse ntse hauv chav kuaj.
FAQ
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